The Game Boy Advance version of Crash of the Titans features linear 2D gameplay where the focus is to break crates while jacking Titans, it also has its own story merging the DS and console versions.

Neo Cortex is back and has corrupted the Tiki powers of Wumpa Island to create hundreds of strange, titanic monsters! Fortunately, Crash is ready for him and has learned new combat and acrobatic abilities to hijack these large outrageous mutants and use their powers against each other and eventually defeat Neo Cortex's new Doominator Robot.