Revenge of Monkey Fist is a sidescrolling platformer where players take control of Kim Possible. Kim has an assortment of punches, kicks and acrobatic moves that she can use to dispatch enemies. She's not short of high-tech gadgets, either: she can use laser lipstick, compact case bombs, invincibility watches, to name a few. Kim's buddy Wade can also contact her from time to time to provide Kim with useful tips and hints.

Kim Possible's buddy Ron Stoppable has been kidnapped by the evil ninja master, Monkey Fist! Help Kim battle her way through familiar foes such as Dr. Drakken, Shego, and of course, Monkey Fist, as you travel across the globe and search far and wide for Ron.